Genetic Risk Factors of Bronchopulmonary Dysplasia

Environmental And Genetic Risk Factors For Bronchopulmonary Dysplasia In Neonates

Bronchopulmonary dysplasia: incidence and risk factors.

INTRODUCTION Bronchopulmonary dysplasia is the most common chronic pulmonary sequela among very low birth weight infants. The objective of this study was to estimate its incidence in our Neonatal Unit over the past 5 years and analyze associated risk factors. POPULATION AND METHODS An observational and analytical study was conducted in a retrospective cohort, using data obtained from a prospe...

Genetic and Epidemiological Risk Factors in the Development of Bronchopulmonary Dysplasia

Bronchopulmonary dysplasia (BPD) is the chronic lung disease of preterm infants and still represents a major burden of prematurity. Several clinical risk factors for the onset of the disease are already known. In addition, some candidate genes have recently been identified. We set out to determine clinical as well as genetic risk factors for the development of BPD in the German population. 155 ...

Prenatal and postnatal risk factors for developing bronchopulmonary dysplasia

Aim. To determine prenatal and postnatal risk factors for developing bronchopulmonary dysplasia in infants < 30 weeks of gestational age. Methods. Over a 22-month period, 115 newborns were enrolled in the study. Details including gestational age, sex, birth weight, prenatal steroids, surfactant treatment, ventilatory support, days of postnatal oxygen requirement, late onset sepsis/ pneumonia, a...

The genetic basis for bronchopulmonary dysplasia.

While the 'original' bronchopulmonary dysplasia (BPD) was attributed to the iatrogenic effects of oxygen and barotrauma on the preterm lung, analyses of the 'new' BPD suggests that these environmental effects may contribute to arrested pulmonary development, and that there may also be genetic foundations for the susceptibility to BPD. Twinning, family and population studies implicate heritable ...